Indicators
CHEK1 Gene
This gene is involved in the negative regulation of cell growth.
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Indicators
This gene is involved in the negative regulation of cell growth.
Indicators
This gene is involved in the modulation of transcription.
Indicators
Coagulation factor IX (461 aa, ~52 kDa) is encoded by the human F9 gene. This protein plays a role in the intrinsic pathway of blood coagulation through the mediation of proteolysis that converts factor X into an active protease.
Indicators
Coagulation factor VII (466 aa, ~52 kDa) is encoded by the human F7 gene. This protein is involved in both binding to tissue factor and the initiation of blood coagulation.
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Coagulation factor X (488 aa, ~55 kDa) is encoded by the human F10 gene. This protein is involved in proteolysis and blood coagulation.
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Coagulation factor XI (625 aa, ~70 kDa) is encoded by the human F11 gene. This protein is involved in the proteolytic activation of coagulation factor IX.
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Coagulation factor XII (615 aa, ~68 kDa) is encoded by the human F12 gene. This protein is involved in blood coagulation and fibrinolysis.
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Complement C2 (752 aa, ~83 kDa) is encoded by the human C2 gene. This protein is involved in post-translational protein processing and complement activity.
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Complement C5 (1676 aa, ~188 kDa) is encoded by the human C5 gene. This protein is involved in complement-mediated immunity.
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A protein complex composed of 18 complement component 1q (C1q) subcomponent chains: six C1qA, six C1qB and six C1qC. The C1q complex is part of the complement component C1 complex (C1 complex) and undergoes confirmational rearrangement following binding of pentraxins or antigen-antibody complexes that include either immunoglobulin M (IgM) or several IgG molecules. These confirmational changes activate the C1r chains of the C1 complex, which, in turn, cleaves C1s chains of the C1 complex. Following C1s cleavage, the C1 complex can proteolytically activate C2 and C4 and promotes formation of C3-convertase, which cleaves C3 and activates the classical complement pathway.
Indicators
Complement component C6 (934 aa, ~105 kDa) is encoded by the human C6 gene. This protein is involved in complement-mediated host defense responses.
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Complement component C7 (843 aa, ~94 kDa) is encoded by the human C7 gene. This protein is involved in insertion of the membrane attack complex in lipid bilayers.