Indicator Explainer
Coagulation Factor XI
Coagulation factor XI (625 aa, ~70 kDa) is encoded by the human F11 gene. This protein is involved in the proteolytic activation of coagulation factor IX.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C201572. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
Related Tests
Tests that measure or involve this indicator.
References
- NCI Thesaurus 26.09d — Coagulation Factor XI (C201572)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C201572. NCI definition, reproduced without modification under CC BY 4.0.
- Gene variants in a family with inherited coagulation factor XI deficiency and identification of novel mutations. — Thromb Res, 2026-04-22 (PMID 42035727; literature)
- Coagulation factor XI as a protector against heart failure: Diverse effects and potential threats. — Kardiol Pol, 2026-04-13 (PMID 41972897; literature)
- Targeting coagulation factor XI/XIa for anticoagulation therapy: from mechanism to drug development. — Biochem Pharmacol, 2026-10-23 (PMID 42918316; literature)
- RNA interference therapy targeting coagulation factor XI: a first-in-human trial of RBD4059 (vortosiran). — Blood Adv, 2026-04-01 (PMID 41512172; literature)
- Clinical characteristics and genetic variant spectrum of 27 patients with coagulation factor XI deficiency. — Hum Genet, 2026-02-24 (PMID 41733767; literature)
- Coagulation factor XI and cardiovascular disease: A complex, cardio-specific conundrum. — Med, 2026-02-01 (PMID 41690296; literature)