Indicator Explainer
Coagulation Factor XII
Coagulation factor XII (615 aa, ~68 kDa) is encoded by the human F12 gene. This protein is involved in blood coagulation and fibrinolysis.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C104219. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — Coagulation Factor XII (C104219)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C104219. NCI definition, reproduced without modification under CC BY 4.0.
- Development of an Interpretable QSAR Model for Predicting Coagulation Factor XIIa Inhibitors Using Ensemble Machine Learning. — Pharmaceuticals (Basel), 2026-09-09 (PMID 42797471; literature)
- Instrument-specific reference intervals for coagulation factor XII and antithrombin III: A regional study in Jiangsu, China. — J Immunol Methods, 2026-08-27 (PMID 42660278; literature)
- Coagulation factor XII deficiency alleviates vascular dysfunction and cognitive impairment in a mouse model of cerebral β-amyloidosis and cerebral amyloid angiopathy. — Aging Brain, 2026-08-25 (PMID 42699154; literature)
- Chinensinaphthol methyl ether prevents thrombosis by inhibiting the intrinsic pathway of coagulation through targeting coagulation factor XII. — Phytomedicine, 2026-03-19 (PMID 41935466; literature)
- A Case Report of Coagulation Factor XII Deficiency. — Clin Lab, 2026-01-01 (PMID 41543089; literature)
- Thiol isomerase ERp46 catalyzes the disulfide formation of coagulation factor XII enhancing its activity. — J Thromb Haemost, 2025-11-04 (PMID 41197808; literature)