Loading
Search products, companies, tests, and guides — go from query to quote request in one place.
Technology
A laboratory procedure for the detection or identification of proteins or peptides that have been separated by gel electrophoresis and transferred onto nitrocellulose or other type of paper or nylon membrane. The proteins are then detected by reaction with enzymatically labeled or radiolabeled antibody probes.
Indicators
A family of globular proteins found in many plant and animal tissues that tend to bind a wide variety of ligands. Albumin is the main protein in blood plasma. Low serum levels occur in conditions associated with malnutrition, inflammation and liver and kidney diseases.
Glossary Term
A volatile liquid prepared by fermentation of certain carbohydrates. Alcohol acts as a central nervous system (CNS) depressant, a diuretic, and a disinfectant. Although the exact mechanism of CNS depression is unknown, alcohol may act by inhibiting the opening of calcium channels, mediated by the binding of the inhibitory neurotransmitter gamma-amino butyric acid (GABA) to GABA-A receptors, or through inhibitory actions at N-methyl-D-aspartate (NMDA)-type glutamate receptors. Alcohol inhibits the production of antidiuretic hormone, thereby producing diuresis that may lead to dehydration. This agent kills organisms by denaturing their proteins.
Tests
An allergy blood test measures the amount of allergy-causing antibodies called immunoglobulin E (IgE). Antibodies are proteins that your immune system makes to fight foreign substances, such as viruses and bacteria . But your immune system may also make them in response to allergens. These are harmless substances, such as pollen and peanuts, that may cause an allergic reaction in some people.
Indicators
Alpha-2-macroglobulin (1474 aa, ~163 kDa) is encoded by the human A2M gene. This protein has activity as a protease inhibitor.
Glossary Term
Alternate Splicing is a process in which multiple protein isoforms or products are generated from a single gene as a result of splicing together different nonconsecutive exons during the processing of initially identical nascent transcripts of a gene into mature mRNA transcripts. An exon may be connected to any one of several alternative exons to form the mRNA and generate related proteins, often in a tissue or developmental stage specific manner.
Tests
An ANA test is a blood test that looks for antinuclear antibodies in your blood. Antibodies are proteins that your immune system makes to fight foreign substances, like viruses and bacteria. But an antinuclear antibody attacks your healthy cells instead. It's called "antinuclear" because it targets the nucleus of the cells, which is in charge of sending signals that are needed for important cell functions.
Tests
The determination of the amount of a complex comprised of angiopoietin-related proteins 3 and 8 in a sample.
Indicators
An antinuclear antibody directed against 52 or 60 kDa RNA-binding proteins in the nucleus. They can be associated with multiple autoimmune disorders, primarily Sjogren syndrome and system lupus erythematosus. Maternal anti-Ro antibody positivity can be associated with neonatal lupus.
Tests
Antibody serology tests look for specific antibodies in your blood. Antibodies are proteins your immune system makes to fight disease-causing germs (also called pathogens), such as viruses and bacteria .
Tests
An ANCA test looks for antineutrophil cytoplasmic antibodies (ANCA) in a sample of your blood. Antibodies are proteins that your immune system makes to fight foreign substances, such as viruses and bacteria. ANCAs, however, are autoantibodies, which are antibodies that attack your own healthy tissues and organs by mistake. This can lead to the development of an autoimmune disease .
Indicators
Antithrombin-III (464 aa, ~53 kDa) is encoded by the human SERPINC1 gene. This protein is involved in the negative regulation of serine proteinase activity during blood coagulation.
