Glossary Term
Alternate Splicing
Definition
Alternate Splicing is a process in which multiple protein isoforms or products are generated from a single gene as a result of splicing together different nonconsecutive exons during the processing of initially identical nascent transcripts of a gene into mature mRNA transcripts. An exon may be connected to any one of several alternative exons to form the mRNA and generate related proteins, often in a tissue or developmental stage specific manner.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C16280. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
References
- NCI Thesaurus 26.09d — Alternate Splicing (C16280)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C16280. NCI definition, reproduced without modification under CC BY 4.0.
- Alternate splicing converts human CD137 from costimulatory to immunosuppressive function. — J Autoimmun, 2025-11-07 (PMID 41205341; literature)
