Indicator Explainer
Alpha-2-Macroglobulin
Alpha-2-macroglobulin (1474 aa, ~163 kDa) is encoded by the human A2M gene. This protein has activity as a protease inhibitor.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C105924. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — Alpha-2-Macroglobulin (C105924)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C105924. NCI definition, reproduced without modification under CC BY 4.0.
- Alpha-2-Macroglobulin-Enriched Plasma Modulates Inflammatory and Proteolytic Pathways in Experimental Equine Musculoskeletal Models. — Animals (Basel), 2026-08-19 (PMID 42652000; literature)
- Effects of nebulized alpha-2 macroglobulin in horses with lower airway inflammation. — J Equine Vet Sci, 2026-07-03 (PMID 42398595; literature)
- Alpha-2-macroglobulin attenuates glucocorticoid-induced osteonecrosis of the femoral head by enhancing osteogenesis and antioxidant defense via the Akt/Nrf2 signaling pathway. — J Mol Histol, 2026-06-29 (PMID 42371161; literature)
- Pilot Study of an Alpha-2-Macroglobulin-Enriched Plasma-Derived Orthobiologic Preparation in Sport Horses with Chronic Degenerative Joint Disease. — Vet Sci, 2026-05-29 (PMID 42357734; literature)
- Effect of nutritional intervention on interleukin-18 and alpha-2-macroglobulin in women with obesity and metabolic dysfunction-associated fatty liver disease: a prospective cohort study. — J Health Popul Nutr, 2026-05-11 (PMID 42116229; literature)
- Ultrasound-Guided Hydrodissection for Carpal Tunnel Syndrome with Bifid Median Nerve and Persistent Median Artery: An Imaging-Based Case Report with Alpha-2 Macroglobulin. — Diagnostics (Basel), 2026-04-30 (PMID 42122067; literature)