Indicator Explainer
Antithrombin-III
Antithrombin-III (464 aa, ~53 kDa) is encoded by the human SERPINC1 gene. This protein is involved in the negative regulation of serine proteinase activity during blood coagulation.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C104683. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-19. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — Antithrombin-III (C104683)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C104683. NCI definition, reproduced without modification under CC BY 4.0.
- Pediatric Dilated Cardiomyopathy With Suspected Hereditary Protein C/S and Antithrombin III Deficiency Presenting as Ischemic Stroke-A Rare Case Report. — Case Rep Pediatr, 2026-10-07 (PMID 42851964; literature)
- Site-specific glycosylation of serum antithrombin-III as a potential biomarker for AFP-negative HCC. — Clin Chim Acta, 2026-09-10 (PMID 42722123; literature)
- Instrument-specific reference intervals for coagulation factor XII and antithrombin III: A regional study in Jiangsu, China. — J Immunol Methods, 2026-08-27 (PMID 42660278; literature)
- Admission antithrombin III activity as a risk-enrichment marker for septic shock below the ISTH overt-DIC threshold. — Front Med (Lausanne), 2026-07-31 (PMID 42602135; literature)
- Antithrombin III use in pediatric and neonatal ECMO: A systematic review and meta-analysis. — Perfusion, 2026-10-18 (PMID 42893484; literature)
- Complementing the picture: adding antithrombin III monitoring in extracorporeal carbon dioxide removal. — Am J Respir Crit Care Med, 2026-10-16 (PMID 42885552; literature)
- Reply to Wang et al.: Complementing the picture: adding antithrombin III monitoring in extracorporeal carbon dioxide removal. — Am J Respir Crit Care Med, 2026-10-16 (PMID 42885556; literature)