Glossary Term
Non-Parametric Test
In statistical inference procedures (hypothesis tests and confidence intervals), nonparametric procedures are those that are relatively free of assumptions about population parameters.
Loading
Loading
Search products, companies, tests, and guides — go from query to quote request in one place.
Glossary Term
In statistical inference procedures (hypothesis tests and confidence intervals), nonparametric procedures are those that are relatively free of assumptions about population parameters.
Glossary Term
A point mutation occurring within the protein-coding region of a gene, and which codes for a stop that can truncate the protein.
Glossary Term
A family of probability density functions whose mean, median and mode are identical. The function generates a symmetrical curve, whose position and shape is determined by its location and scale parameters, the mean and standard deviation respectively. The standard normal distribution has a location parameter of 0 and a scale parameter of 1.
Glossary Term
Laboratory procedure in which single stranded nucleic acids are allowed to interact so that complexes, or hybrids, are formed by molecules with sufficiently similar, complementary sequences. By this means the degree of sequence identity can be assessed and specific sequences detected. (From Biology-online)
Glossary Term
Nucleotide Excision Repair (NER) mends DNA regions that contain chemical adducts, such as UV-induced thymine dimers or carcinogenic adducts, which distort the DNA helix and interfere with replication and transcription. NER is targeted to actively transcribed regions of the genome. During NER in eukaryotes, shape irregularities are detected by protein complexes that slide along the DNA molecule and induce cuts on each side of a lesion several nucleotides away. Removal of the damaged 25-30 nucleotide fragment is followed by repair synthesis and ligation.
Glossary Term
A measure of the probability that a result happened by chance. The lower the p-value, the more likely it is that the result was caused by phenomenon of interest.
Glossary Term
In statistical inference procedures (hypothesis tests and confidence intervals), parametric procedures are those that incorporate assumptions about population parameters.
Glossary Term
A score reported on a logarithmic scale representing the probability that a nucleotide base was incorrectly called by the base caller.
Glossary Term
A distribution function used to describe the occurrence of rare events or to describe the sampling distribution of isolated counts in a continuum of time or space. This special probability distribution can apply to the number of discrete independent random events occurring in a given interval when knowing their average rate of occurrence over a very long interval.
Glossary Term
The enzymatic processing of a polypeptide chain after translation from messenger RNA and after peptide bond formation has occurred. Examples include glycosylation, acylation, limited proteolysis, phosphorylation, isoprenylation.
Glossary Term
Chemicals that are added to drug products to prolong shelf life and maintain sterility. Protection of formulations, especially aqueous solutions, against microbial growth requires use of either antibacterial or antifungal preservatives. Generally, such agents are active against either bacteria or fungi but a few are active against both. The antimicrobials include but not limited to chlorobutanol, benzyl alcohol, sodium benzoate, sorbic acid, and phenol. The antioxidizing agents include butylated hydroxytoluene, hydroxyanisole, propyl gallate, and sulfites. The necessary addition of preservatives for both safety and economy sometimes has been associated with significant adverse effects in certain patient populations.
Glossary Term
An enzymatic pre-treatment in nucleic-acid extraction that degrades proteins and nucleases, releasing nucleic acids from clinical material before binding, wash, and elution steps.