Glossary Term
Nucleotide Excision Repair
Definition
Nucleotide Excision Repair (NER) mends DNA regions that contain chemical adducts, such as UV-induced thymine dimers or carcinogenic adducts, which distort the DNA helix and interfere with replication and transcription. NER is targeted to actively transcribed regions of the genome. During NER in eukaryotes, shape irregularities are detected by protein complexes that slide along the DNA molecule and induce cuts on each side of a lesion several nucleotides away. Removal of the damaged 25-30 nucleotide fragment is followed by repair synthesis and ligation.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C20213. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
References
- NCI Thesaurus 26.09d — Nucleotide Excision Repair (C20213)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C20213. NCI definition, reproduced without modification under CC BY 4.0.
- Assessment and detection of nucleotide excision repair capability in human cells: a critical review of current functional methods. — Mol Biol Rep, 2026-09-27 (PMID 42801347; literature)
- Genetic analysis of epistasis between nucleotide excision repair and homologous recombination in the recovery of persisters after fluoroquinolone treatment. — PLoS Genet, 2026-09-21 (PMID 42766644; literature)
- Deleting the 2B domain of mycobacterial UvrD1 unmasks a latent helicase activity in vitro but effaces UvrD1 activity in nucleotide excision repair in vivo. — Nucleic Acids Res, 2026-09-01 (PMID 42847243; literature)