Glossary Term
Nonsense Mutation
PCR TermsEN
Definition
A point mutation occurring within the protein-coding region of a gene, and which codes for a stop that can truncate the protein.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C62198. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
Nonsense MutationPremature Termination AbnormalityPremature Termination MutationStop Gain
References
- NCI Thesaurus 26.09d — Nonsense Mutation (C62198)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C62198. NCI definition, reproduced without modification under CC BY 4.0.
- Targeting FTSJ1 to Restore TP53 Function in Nonsense Mutation-Driven Cancer: Computational and Experimental Evaluation of 1,2,4-Triazole Derivatives. — Molecules, 2026-10-16 (PMID 42943779; literature)