Glossary Term
Nucleic Acid Hybridization
PCR TermsEN
Definition
Laboratory procedure in which single stranded nucleic acids are allowed to interact so that complexes, or hybrids, are formed by molecules with sufficiently similar, complementary sequences. By this means the degree of sequence identity can be assessed and specific sequences detected. (From Biology-online)
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C16924. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-18. No individual clinical interpretation or human reviewer is asserted.
Also Known As
HybridizationMolecular Biology, Molecular HybridizationNucleic Acid Hybridization
References
- NCI Thesaurus 26.09d — Nucleic Acid Hybridization (C16924)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C16924. NCI definition, reproduced without modification under CC BY 4.0.
- Mismatch-Tuned Plasmonic Nanogap Networks on Block Copolymers for Ultrasensitive Nucleic Acid Quantification. — ACS Nanosci Au, 2026-04-14 (PMID 42631079; literature)
- Activation of enzymatic catalysis via nucleic acid hybridization affords synergistic coupling of specificity, potency, and signal amplification. — Nat Commun, 2025-10-31 (PMID 41173859; literature)
- CONVERT: Dynamic crRNA Reconfiguration for Universal One-Pot CRISPR/Cas12a-Based Nucleic Acid Detection. — Anal Chem, 2025-08-18 (PMID 40825745; literature)
- Benchmarking a massively parallel nucleic acid hybridization platform for monitoring biomarkers of public health significance in wastewater. — Water Res, 2025-07-08 (PMID 40669231; literature)
- A microchip electrophoresis method for rapid nucleic acid extraction and bacteria detection. — Talanta, 2025-06-20 (PMID 40570436; literature)
- Affinity Chromatography With Selective Nucleic Acid Hybridization: Direct Coupling With Size Exclusion Chromatography. — J Sep Sci, 2026-10-01 (PMID 42888955; literature)
- Rotational Microfluidic Paper-Based Chip Platform Integrating Nucleic Acid Sequence-Based Amplification for Visual and Sensitive Detection of Viable Pathogens. — ACS Meas Sci Au, 2026-07-31 (PMID 42921439; literature)