Glossary Term
Post-Translational Modification
PCR TermsEN
Definition
The enzymatic processing of a polypeptide chain after translation from messenger RNA and after peptide bond formation has occurred. Examples include glycosylation, acylation, limited proteolysis, phosphorylation, isoprenylation.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C17019. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
Post Translational ModificationPost-Translational ModificationPost-Translational Modification AlterationPosttranslational ModificationProtein ModificationProtein/Amino Acid Biochemistry, Post-Translational Modification
References
- NCI Thesaurus 26.09d — Post-Translational Modification (C17019)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C17019. NCI definition, reproduced without modification under CC BY 4.0.
- Identification of Transcriptome-Derived Candidate Genes Associated with Post-Translational Modification Gene Sets in Neonatal Hypoxic-Ischemic Encephalopathy. — J Mol Neurosci, 2026-10-15 (PMID 42878948; literature)
- ProCAS: Multi-Lysine Post-Translational Modification Site Prediction Based on the SPUS Algorithm and the ProCAS Architecture. — Mol Cell Proteomics, 2026-10-13 (PMID 42869297; literature)
- Comparative S-acyl-proteomics reveals post-translational modulation of fungal purine metabolism for Verticillium wilt. — PLoS Pathog, 2026-10-26 (PMID 42932396; literature)