Glossary Term
Open Reading Frame
A sequence of nucleotides in that contains no termination codons and so can potentially translate as a polypeptide chain.
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Glossary Term
A sequence of nucleotides in that contains no termination codons and so can potentially translate as a polypeptide chain.
Technology
A molecular genetic technique that isolates and sequences chromosomal regions that are rich in open chromatin. First, nuclei are harvested from a cellular sample. Then a hyperactive Tn5 transposase is added to the nuclei where it excises non-nucleosomal DNA strands and ligates co-administered high-throughput sequencing adapters (tagmentation). The tagged DNA fragments are isolated, amplified by PCR and sequenced. The number of reads for specific region of DNA correlate with increased chromatin accessibility and this method can identify regions of transcription factor and nucleosome binding.
Technology
Technique of electron microscopy in which the specimen is coated with heavy metal and then scanned by an electron beam. The resolution is not as great as with transmission electron microscopy, but preparation is easier (often by fixation followed by critical point drying), the depth of focus is relatively enormous, the surface of a specimen can be seen (though not the interior unless the specimen is cracked open) and the image is aesthetically pleasing.
Artículo
Research record from Microbiol Spectr, 2026-08-15. PMID 42603138.
Artículo
Research record from BMJ Open Respir Res, 2026-03-27. PMID 41895789.
Artículo
Research record from Open Vet J, 2026-05-31. PMID 42375448.
Artículo
Research record from Pharmacoecon Open, 2026-07-10. PMID 42432212.
Artículo
Research record from Open Forum Infect Dis, 2026-06-25. PMID 42403910.
Artículo
Research record from Trop Med Infect Dis, 2026-06-18. PMID 42347553.
Artículo
Instrument compatibility screening for molecular assays: open versus closed architectures, building the compatibility matrix, and pricing lock-in risk.
Artículo
Research record from BMJ Open, 2026-08-11. PMID 42580827.
Artículo
Research record from Open Forum Infect Dis, 2026-07-04. PMID 42444789.