Glossary Term
Open Reading Frame
A sequence of nucleotides in that contains no termination codons and so can potentially translate as a polypeptide chain.
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Glossary Term
A sequence of nucleotides in that contains no termination codons and so can potentially translate as a polypeptide chain.
Technology
A molecular genetic technique that isolates and sequences chromosomal regions that are rich in open chromatin. First, nuclei are harvested from a cellular sample. Then a hyperactive Tn5 transposase is added to the nuclei where it excises non-nucleosomal DNA strands and ligates co-administered high-throughput sequencing adapters (tagmentation). The tagged DNA fragments are isolated, amplified by PCR and sequenced. The number of reads for specific region of DNA correlate with increased chromatin accessibility and this method can identify regions of transcription factor and nucleosome binding.
Technology
Technique of electron microscopy in which the specimen is coated with heavy metal and then scanned by an electron beam. The resolution is not as great as with transmission electron microscopy, but preparation is easier (often by fixation followed by critical point drying), the depth of focus is relatively enormous, the surface of a specimen can be seen (though not the interior unless the specimen is cracked open) and the image is aesthetically pleasing.
Article
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Instrument compatibility screening for molecular assays: open versus closed architectures, building the compatibility matrix, and pricing lock-in risk.
Article
Research record from BMJ Open, 2026-08-11. PMID 42580827.
Article
Research record from Open Forum Infect Dis, 2026-07-04. PMID 42444789.