Hepatitis C Virus RNA Quantification

What it is for

A reactive HCV antibody screen requires HCV RNA to confirm active infection. Quantitative RNA sets the baseline before direct-acting antiviral therapy, and sustained virologic response is confirmed by undetectable RNA at week 12 after treatment completion.

Limitations

Antibody-positive but RNA-negative means resolved past infection, not immunity. False-low results can occur with poor specimen handling; the assay cannot determine genotype unless a separate assay is run.

Before you test

For individuals: one blood draw confirms whether the virus is present. If you have ever injected drugs or received a blood transfusion before screening, discuss testing with your clinician.

Health information only. This guide does not diagnose or replace advice from a healthcare professional.

Also known as

• HCV RNA
• HCV viral load