Glossary Term
Deoxyribonucleotide Triphosphate
A nucleotide comprised of either a purine or pyrimidine nitrogenous base bound to a deoxyribose sugar esterified with three phosphate groups. These molecules are essential for DNA synthesis.
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Glossary Term
A nucleotide comprised of either a purine or pyrimidine nitrogenous base bound to a deoxyribose sugar esterified with three phosphate groups. These molecules are essential for DNA synthesis.
Glossary Term
Quantity of dimension one used to express on a scale from 0 to 14 the amount-of-substance concentration of hydrogen ion of dilute aqueous solution, calculated as the logarithm of the reciprocal of hydrogen-ion concentration in gram atoms per liter.
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The assemblage of traits or outward appearance of an individual. It is the product of interactions between genes and between genes and the environment.
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A score reported on a logarithmic scale representing the probability that a nucleotide base was incorrectly called by the base caller.
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The goodness of fit statistic for the terminal elimination phase, adjusted for the number of time points used in the estimation of Lambda z.
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The area between the x-axis and the curve given by the integrand. It is equal to the definite integral of a function. In the field of pharmacokinetics, the area under the curve (AUC) is the area under the curve in a plot of concentration of a drug in plasma against time. AUC is usually given for the time interval zero to infinity, and other time intervals are indicated.
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Existing conditions, especially those that would be confused with the phenomenon to be observed or measured.
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Initiation of DNA base excision repair (BER) involves a DNA glycosylase that binds the altered deoxynucleoside in an extrahelical position and catalyzes cleavage of the base-sugar bond. Subsequently, an AP endonuclease or AP lyase activity incises the abasic site, followed by short-patch gap-filling, excision of the base-free sugar-phosphate residue, and ligation.
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An ionic compound that resists changes in its pH.
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Enzymatic (e.g. dUTP/UNG) and physical measures that stop amplified DNA from contaminating later runs. Labs with high daily volumes usually require dUTP/UNG chemistry in purchased assays; confirm this when comparing kits from different manufacturers.
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The genetic material of the nucleus, consisting of deoxyribonucleoprotein, which occurs in two forms during the phase between mitotic divisions: 1) as heterochromatin, seen as condensed, readily stainable clumps; 2) as euchromatin, dispersed lightly staining or nonstaining material. During mitotic division the chromatin condenses into chromosomes.
Glossary Term
Enzymes that catalyze the hydrolytic cleavage of phosphodiester bond linkages in the DNA backbone. Deoxyribonucleases belong to a larger family of nucleases, which cleave DNA bases at various positions in the DNA backbone.