Glossary Term
Base Excision Repair
PCR TermsEN
Definition
Initiation of DNA base excision repair (BER) involves a DNA glycosylase that binds the altered deoxynucleoside in an extrahelical position and catalyzes cleavage of the base-sugar bond. Subsequently, an AP endonuclease or AP lyase activity incises the abasic site, followed by short-patch gap-filling, excision of the base-free sugar-phosphate residue, and ligation.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C20212. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
Base Excision RepairBERDNA Base Excision Repair
References
- NCI Thesaurus 26.09d — Base Excision Repair (C20212)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C20212. NCI definition, reproduced without modification under CC BY 4.0.
- Photobiomodulation alters base excision repair gene expression in an experimental model of arthritis. — Photochem Photobiol, 2026-09-30 (PMID 42814372; literature)
- Exponential strand displacement amplification-assisted microchip electrophoresis for rapid and simultaneous detection of base excision repair enzymes. — J Chromatogr A, 2026-09-23 (PMID 42815109; literature)