Tests
Exon RNA Measurement
The determination of the amount of RNA encoded by a specific exon in a biological sample.
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Tests
The determination of the amount of RNA encoded by a specific exon in a biological sample.
Glossary Term
An Exonuclease is a hydrolase (nuclease) that specifically catalyzes the hydrolysis of terminal phosphodiester bonds of deoxyribonucleotide or ribonucleotide chains, releasing mononucleotides.
Glossary Term
The sequences of a gene that are present in the final, mature, spliced messenger RNA molecule from that gene.
Technology
A procedure that can determine the DNA sequence for all of the exons in an individual.
Glossary Term
Alternate Splicing is a process in which multiple protein isoforms or products are generated from a single gene as a result of splicing together different nonconsecutive exons during the processing of initially identical nascent transcripts of a gene into mature mRNA transcripts. An exon may be connected to any one of several alternative exons to form the mRNA and generate related proteins, often in a tissue or developmental stage specific manner.
Indicators
A fusion gene that results from a translocation t(9;22)(q34;q11) that fuses the 5' part of the BCR gene to the 5' side of exon 2 of the ABL1 gene. There are 3 potential products that are formed depending on which BCR exon has the breakpoint. All of the protein products have constitutively active tyrosine kinase activity. This fusion is associated with both chronic myeloid leukemia and acute lymphoblastic leukemia.
Glossary Term
Removal of introns from mRNA precursors and the reattachment or annealing of exons.