Glossary Term
Inversion
The act of turning inside out, upside down, or end-for-end.
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Glossary Term
The act of turning inside out, upside down, or end-for-end.
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The weighted concentration of ions in solutions.
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The chromosomal morphology and number in somatic cells of an individual.
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Major class of enzymes that catalyze the linking together of two molecules (EC class 6) for example DNA ligases that link two fragments of DNA by forming a phosphodiester bond.
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A molecule of RNA 200-17000 nucleotides in length that is transcribed by non-protein coding areas of DNA. These ribonucleotides may play a role in a variety of biological processes.
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A genetic variation where gain, loss, or exchange of DNA results in monoallelic loss of function mutations in a diploid cell. In the context of tumor suppressor genes, where a single copy is sufficient for functionality, loss of function for the second allele is associated with tumorigenesis.
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A class of RNA molecule containing protein-coding information in its nucleotide sequence that can be translated into the amino acid sequence of a protein.
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The quantity and identity of all of the low molecular weight molecules in a biological entity or sample that are products of or participants in various metabolic processes.
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Metabolomics is the study of the biological metabolic profile of a cellular specimen in a specific environment at an isolated timepoint. This discipline depicts the physiological states of cells and organisms by focusing on carbohydrates, lipids, and other metabolites. Several analytical techniques are utilized to quantify the metabolic content of specimens such as mass spectrometry and electrophoretic applications.
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The covalent chemical or biochemical addition of a methyl group(s) to a compound. (NCI)
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A sequence of single-stranded RNA, that is 20-25 nucleotides in length, which is transcribed from DNA but is not translated into a protein. This nucleic acid may regulate the transcription or translation of other genes.
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Genomic instability associated with the presence of hypermutability in specific genetic marker regions resulting from defective DNA mismatch repair.