Glossary Term
Ligase
PCR TermsEN
Definition
Major class of enzymes that catalyze the linking together of two molecules (EC class 6) for example DNA ligases that link two fragments of DNA by forming a phosphodiester bond.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C16796. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
EC 6Ligase
References
- NCI Thesaurus 26.09d — Ligase (C16796)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C16796. NCI definition, reproduced without modification under CC BY 4.0.
- Co-opted CHIP E3 Ub-ligase provides protein quality control by regulating molecular properties of condensates formed by a positive-strand RNA virus. — Sci Adv, 2026-10-16 (PMID 42886786; literature)
- Disruption of the CRL5 ubiquitin ligase complex enhances engineered T-cell persistence under chronic tumor antigen exposure. — Cancer Immunol Res, 2026-10-15 (PMID 42878665; literature)
- Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis. — Mol Cell, 2026-10-20 (PMID 42901160; literature)
- MG53 suppresses the progression of bladder cancer through E3 ubiquitin ligase-mediated degradation of AMPKα. — Med Oncol, 2026-10-20 (PMID 42900341; literature)
- Atypical E3 ligase HOIL1 promotes MDA5 signaling and ester-linked ubiquitination of LGP2. — mBio, 2026-10-22 (PMID 42910928; literature)
- Mitochondrial membrane rupture licenses prohibitin 2-mediated bacterial tethering and E3 ligase recruitment to drive mito-xenophagy. — Autophagy, 2026-10-25 (PMID 42926334; literature)
- THE UBC8-GID E3 UBIQUITIN LIGASE MODULE IS REQUIRED FOR STRESS RESPONSE IN CANDIDA ALBICANS. — J Biol Chem, 2026-10-28 (PMID 42951139; literature)
- FBXO22 is a promising E3 ubiquitin ligase for targeted protein degradation. — Curr Opin Chem Biol, 2026-10-28 (PMID 42950695; literature)