Glossary Term
Microsatellite Instability
PCR TermsEN
Definition
Genomic instability associated with the presence of hypermutability in specific genetic marker regions resulting from defective DNA mismatch repair.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C36318. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
Microsatellite InstabilityMicrosatellite Instability PositiveMicrosatellite Instability PresentMSIMSI PositiveMSI Present
References
- NCI Thesaurus 26.09d — Microsatellite Instability (C36318)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C36318. NCI definition, reproduced without modification under CC BY 4.0.
- Distinct genomic landscapes of mismatch-repair deficiency (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancer depending on tumor mutation burden (TMB) levels. — J Immunother Cancer, 2026-10-15 (PMID 42880820; literature)
- Nivolumab-Ipilimumab for Localized Microsatellite Instability-High Gastric/Gastroesophageal Junction Adenocarcinoma: The Phase 2 NEONIPIGA Nonrandomized Clinical Trial. — JAMA Oncol, 2026-10-15 (PMID 42879140; literature)
- Pan-cancer prevalence of microsatellite instability and Lynch syndrome in India. — Fam Cancer, 2026-10-07 (PMID 42842020; literature)
- Final results of nivolumab plus ipilimumab versus nivolumab or chemotherapy in microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer from CheckMate 8HW. — Ann Oncol, 2026-10-24 (PMID 42926106; literature)