Glossary Term
Methylation
The covalent chemical or biochemical addition of a methyl group(s) to a compound. (NCI)
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Glossary Term
The covalent chemical or biochemical addition of a methyl group(s) to a compound. (NCI)
Tests
The determination of the ratio of micronucleated hepatocytes compared to total hepatocytes present in a sample. The measurement may be expressed as a ratio or percentage.
Glossary Term
A sequence of single-stranded RNA, that is 20-25 nucleotides in length, which is transcribed from DNA but is not translated into a protein. This nucleic acid may regulate the transcription or translation of other genes.
Tests
The determination of the amount of human microRNA 373-3p present in a sample.
Glossary Term
Genomic instability associated with the presence of hypermutability in specific genetic marker regions resulting from defective DNA mismatch repair.
Glossary Term
A variety of simple di-, tri-, tetra-, and pentanucleotide tandem repeats that are dispersed in the euchromatic arms of most chromosomes.
Tests
The determination of the milnacipran in a sample.
Glossary Term
The mismatch repair (MMR) system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. This function is critically dependent on the assembly of multimeric complexes involved in mismatch recognition and signal transduction to downstream repair events.
Glossary Term
A point mutation occurring within the protein-coding region of a gene, and which codes for a different amino acid than expected.
Glossary Term
Required or expected data that is not present, which may be due to non-completion or corruption.
Indicators
This gene is involved in transcriptional promotion in melanocytes.
Indicators
This gene plays a role in DNA mismatch repair.