Indicator Explainer
MLH1 Gene
This gene plays a role in DNA mismatch repair.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C18482. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-19. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — MLH1 Gene (C18482)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C18482. NCI definition, reproduced without modification under CC BY 4.0.
- [A Case of Lynch Syndrome with MLH1 Gene Mutation Identified by Comprehensive Genomic Profiling]. — Gan To Kagaku Ryoho, 2025-12-01 (PMID 41546298; literature)
- Methylation-sensitive high-resolution melting technology is a simple and sensitive method to detect germline epimutation of the MLH1 gene promoter. — Clin Epigenetics, 2025-07-02 (PMID 40604912; literature)
- [A Case of Successful Combination of Immune Checkpoint Inhibitors and Radiotherapy for MLH1 Gene-Deficient Colon Cancer]. — Gan To Kagaku Ryoho, 2025-04-01 (PMID 40360414; literature)
- MLH1 gene promoter methylation status partially overlaps with CpG methylator phenotype (CIMP) in colorectal adenocarcinoma. — Pathol Res Pract, 2024-12-21 (PMID 39724851; literature)
- Green-synthesized silver nanoparticles induced apoptotic cell death in CACO2 cancer cells by activating MLH1 gene expression. — Sci Rep, 2024-11-28 (PMID 39609574; literature)