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Indicators

CTNNB1 Gene

This gene is involved in signal transduction and regulation of transcription.

Indicators

DAXX Gene

This gene plays a role in signal transduction, regulation of transcription and enhancement of apoptosis.

Glossary Term

Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis.

Pcr Terms

Indicators

EED Gene

This gene plays a role in the negative regulation of transcription.

Glossary Term

Enhancer

A 50-150bp DNA sequence that increases the rate of transcription of coding sequences. It may be located at various distances and in either orientation upstream from, downstream from or within a structural gene. When bound by a specific transcription factor it increases the levels of expression of the gene, but is not sufficient alone to cause expression. Distinguished from a promoter, that is alone sufficient to cause expression of the gene when bound.

Pcr Terms

Indicators