Glossary Term
Enhancer
PCR TermsEN
Definition
A 50-150bp DNA sequence that increases the rate of transcription of coding sequences. It may be located at various distances and in either orientation upstream from, downstream from or within a structural gene. When bound by a specific transcription factor it increases the levels of expression of the gene, but is not sufficient alone to cause expression. Distinguished from a promoter, that is alone sufficient to cause expression of the gene when bound.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C13296. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
Enhancer
References
- NCI Thesaurus 26.09d — Enhancer (C13296)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C13296. NCI definition, reproduced without modification under CC BY 4.0.
- c-di-GMP targets the enhancer-binding protein SfnR1 to regulate Pseudomonas aeruginosa growth under sulfur limitation. — Microbiol Res, 2026-10-15 (PMID 42880174; literature)
- A transcriptional cofactor GRIP1 drives PPARγ DNA binding and p300-dependent enhancer activity during homeostatic macrophage polarization. — Sci Adv, 2026-10-14 (PMID 42873853; literature)
- Mechanistic benchmarking of SNAC, DDM, and LLC reveals enhancer-dependent pathways for intestinal semaglutide delivery. — J Control Release, 2026-10-19 (PMID 42896658; literature)
- Targeting Mediator Kinase Attenuates Cardiac Hypertrophy by Regulating Enhancer Utilization. — J Am Heart Assoc, 2026-10-23 (PMID 42924839; literature)
- NF-κB phosphorylation controls enhancer selection to shape the inflammatory gene program. — Immunity, 2026-10-23 (PMID 42914982; literature)
- SMCHD1 loss rewires MYOD1 enhancer nexuses and chromatin accessibility landscapes in muscle cells. — Sci Adv, 2026-10-23 (PMID 42912981; literature)
- An endoplasmic reticulum stress-related gene signature predicts immune therapy response and survival in melanoma: CCAAT/enhancer-binding protein beta serving as a tumor suppressor function verification. — Chin Med J (Engl), 2026-10-26 (PMID 42934089; literature)