Glossary Term
DNA Damage
PCR TermsEN
Definition
Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C16507. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
DNA Damage
References
- NCI Thesaurus 26.09d — DNA Damage (C16507)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C16507. NCI definition, reproduced without modification under CC BY 4.0.
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- ACK1 inhibition suppresses topoisomerase IIα, causing DNA damage accumulation and cellular senescence in RAS mutant lung cancer cells. — Oncogene, 2026-10-28 (PMID 42957742; literature)
- A case for DNA-membrane interactions in the responses to DNA damage. — J Biol Chem, 2026-10-28 (PMID 42951138; literature)