Loading
Search products, companies, tests, and guides — go from query to quote request in one place.
Glossary Term
Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis.
Article
Research record from Clin Chim Acta, 2026-04-20. PMID 42019746.
Tests
A relative measurement (ratio or percentage) of time from the start of the thrombin generation test to the point where a predetermined amount of thrombin is generated.
Glossary Term
A US pathway in which a device maker demonstrates substantial equivalence to a legally marketed predicate. For IVD test kits, 510(k) clearance documents intended use and analytical/clinical support; it is distinct from CLIA waiver, which concerns point-of-care operation settings.
Tests
A stool test detecting hidden blood from the lower bowel; the main screening entry point for colorectal cancer programmes.
Tests
A long-term measure of average blood glucose over roughly the preceding two to three months, used to diagnose and monitor diabetes.
Tests
The hormone detected by pregnancy tests; also used in medicine to assess certain pregnancies and tumours.
Indicators
Immunoglobulin Light Chain Kappa is one of two Ig light chain types. Each Ig molecule is typically composed of two heavy chains and two light chains. Ig kappa light chains contain a variable and a constant region. Kappa light chains are encoded by multiple V, J, and C gene segments, which are separated in the genomes of cells undifferentiated with regard to antibody gene expression. Diversity in the kappa light chain V region arises during differentiation of an activated (kappa-type) antibody-producing B-cell from variable recombination of kappa V genes with kappa J genes and somatic point mutation, which plays a major role in antibody diversity. (from OMIM and NCI)
Indicators
Immunoglobulin Light Chain Lambda is one of two Ig light chain types. Each Ig molecule is typically composed of two heavy chains and two light chains but Ig lambda light chains contain a variable and a constant region. Lambda light chains are encoded by multiple V, J, and C gene segments, which are separated in the genomes of cells undifferentiated with regard to antibody gene expression. During differentiation of an activated (lambda-type) antibody-producing B-cell, diversity in the lambda light chain V region arises from variable recombination of lambda V genes with lambda J genes and somatic point mutation, which plays a major role in antibody diversity. (from OMIM 147220 and NCI)
Article
Research record from Clin Chim Acta, 2026-06-02. PMID 42235732.
Glossary Term
A point mutation occurring within the protein-coding region of a gene, and which codes for a different amino acid than expected.
Article
Research record from J Clin Virol, 2026-09-16. PMID 42759342.
