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An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.
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This gene plays a role in DNA mismatch repair.
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This gene plays a role in DNA mismatch repair mutations in the gene result in hereditary nonpolyposis colorectal cancer-1.
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Direct molecular detection of Mycobacterium tuberculosis complex in respiratory specimens.
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This gene plays a role in the repair of oxidative DNA damage.
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This gene may play a role in the repair of DNA damage that is resolved by recombination.
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This gene is involved in DNA replication and proofreading.
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This gene is involved in both DNA replication and DNA base-excision repair.
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This gene plays a role in DNA double-strand break repair.
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This gene is involved in both homologous recombination and repair of DNA.
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This gene plays a role in the homologous recombination of double-strand DNA breaks.
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This gene is involved in the initiation of DNA replication and sister-chromatid cohesion.
