Indicator Explainer
MSH2 Gene
This gene plays a role in DNA mismatch repair mutations in the gene result in hereditary nonpolyposis colorectal cancer-1.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C18481. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-19. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — MSH2 Gene (C18481)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C18481. NCI definition, reproduced without modification under CC BY 4.0.
- Lynch syndrome caused by a pathogenic SINE-VNTR-Alu (SVA) insertion in MSH2 gene identified by long-read DNA sequencing. — Fam Cancer, 2026-07-09 (PMID 42423801; literature)
- Clinical Discovery and Molecular Analysis of Two Novel MSH2 Gene Mutations (p.Ala771Gly and p.Val797Gly) in Saudi Colorectal Cancer Patients: Potential Implications for Tumorigenesis. — Health Sci Rep, 2026-03-29 (PMID 42005635; literature)
- Aggressive Sebaceous Gland Hyperplasia in a Young Girl With MSH2 Gene Mutation: A Rare Presentation. — Ophthalmic Plast Reconstr Surg, 2024-12-09 (PMID 39652464; literature)
- Association of multilocus sequence typing, MSH2 gene mutations, and antifungal resistance in Candida glabrata: implications for clinical outcomes in Chinese hospitals. — Ann Clin Microbiol Antimicrob, 2024-11-08 (PMID 39516859; literature)
- Exploring the modulation of MLH1 and MSH2 gene expression in hesperetin-treated breast cancer cells (BT-474). — J Adv Pharm Technol Res, 2024-01-15 (PMID 38389973; literature)
- Muir-Torre Syndrome with Novel Mutation in the MSH2 Gene. — Acta Dermatovenerol Croat, 2023-12-01 (PMID 38439724; literature)