Indicator Explainer
POLE Gene
This gene is involved in both DNA replication and DNA base-excision repair.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C106232. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — POLE Gene (C106232)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C106232. NCI definition, reproduced without modification under CC BY 4.0.
- Clinical characterization and analysis of the POLE gene in three Chinese patients with IMAGEI syndrome. — BMC Pediatr, 2026-01-30 (PMID 41618189; literature)
- Progressive decline in old pole gene expression signal enhances phenotypic heterogeneity in bacteria. — Sci Adv, 2024-11-08 (PMID 39514668; literature)