Glossary Term
DNA Ligase
PCR TermsEN
Definition
A family of enzymes that catalyze the formation of phosphodiester bonds to repair broken strands of DNA.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C105960. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
DNA LigaseEC 6.5.1.1Polydeoxyribonucleotide SynthasePolynucleotide Ligase
References
- NCI Thesaurus 26.09d — DNA Ligase (C105960)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C105960. NCI definition, reproduced without modification under CC BY 4.0.
- DNA ligase LigE increases bacterial transformation with damaged extracellular DNA. — FEBS Lett, 2026-10-15 (PMID 42878156; literature)
- Molecular basis of nick ligation in the nucleosome by DNA Ligase IIIα. — Nat Commun, 2026-09-02 (PMID 42830301; literature)
- Cloning and Functional Characterization of AhyAP-T65Lig, an ATP-Dependent DNA Ligase from Trabzonvirus AP-T65. — Mol Biotechnol, 2026-06-29 (PMID 42371265; literature)
- CRISPR/Cas12a-Enhanced Cascade Amplification for Ultra-sensitive DNA Ligase Detection. — Anal Chem, 2026-06-28 (PMID 42366688; literature)