Indicadores
Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI)
Indicadores
A heterodimeric cytokine composed of interleukin-12 subunit beta and interleukin-23 subunit alpha. This complex binds to the interleukin-23 receptor complex, which activates the JAK-STAT signaling pathway and modulates the proliferation, differentiation and effector functions of T-lymphocytes, natural killer cells and some myeloid lineage cells.
Pruebas
The determination of the amount of interleukin 12 beta present in a sample.
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Pruebas
The determination of cellular CD123 expression in a biospecimen.
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Pruebas
The determination of the amount of interleukin-1 alpha present in a sample.
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Pruebas
The determination of the amount of interleukin 1 receptor antagonist present in a sample.
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Pruebas
The determination of the amount of interleukin 1 receptor in a sample.
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Pruebas
The determination of the amount of interleukin 13 present in a sample.
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Pruebas
The determination of the amount of interleukin 14 present in a sample.
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Pruebas
The determination of the amount of interleukin 15 present in a sample.
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Pruebas
The determination of the amount of interleukin 16 present in a sample.
For professionals
Pruebas
The determination of the amount of interleukin 17 present in a sample.
For professionals
