Indicadores
Immunoglobulin Light Chain Kappa is one of two Ig light chain types. Each Ig molecule is typically composed of two heavy chains and two light chains. Ig kappa light chains contain a variable and a constant region. Kappa light chains are encoded by multiple V, J, and C gene segments, which are separated in the genomes of cells undifferentiated with regard to antibody gene expression. Diversity in the kappa light chain V region arises during differentiation of an activated (kappa-type) antibody-producing B-cell from variable recombination of kappa V genes with kappa J genes and somatic point mutation, which plays a major role in antibody diversity. (from OMIM and NCI)
Technology
A laboratory testing method to determine the concentrations of immunoglobulins in the blood.
Diagnostic Methods
Producto
Clinical Chemistry
Producto
Clinical Chemistry
Producto
Clinical Chemistry
Producto
Clinical Chemistry
Pruebas
A proprietary chemiluminescent microparticle immunoassay (CMIA) used for the qualitative detection of IgG antibodies to SARS-CoV-2 in human serum and plasma on the Abbott Alinity i system. The persistence of immunoglobulin class G (IgG) antibodies may identify people who have been infected in the past, recovered from the illness, and possibly developed immunity.
For professionals
Pruebas
A proprietary chemiluminescent microparticle immunoassay (CMIA) used for the qualitative detection of IgG antibodies to SARS-CoV-2 in human serum and plasma on the Abbott ARCHITECT i system. The persistence of immunoglobulin class G (IgG) antibodies may identify people who have been infected in the past, recovered from the illness, and possibly developed immunity.
For professionals
Pruebas
An allergy blood test measures the amount of allergy-causing antibodies called immunoglobulin E (IgE). Antibodies are proteins that your immune system makes to fight foreign substances, such as viruses and bacteria . But your immune system may also make them in response to allergens. These are harmless substances, such as pollen and peanuts, that may cause an allergic reaction in some people.
For everyone & professionals
Indicadores
An autoantibody that reacts with cardiolipin. Different immunoglobulin subclasses and isotypes are associated with different diseases and conditions. Some anticardiolipin antibodies prolong phospholipid dependent clotting while others are associated with spontaneous abortion.
Indicadores
A protein complex comprised of one T-cell surface glycoprotein CD3 delta chain (CD3D), one T-cell surface glycoprotein CD3 gamma chain (CD3G) and two T-cell surface glycoprotein CD3 epsilon chains (CD3E). CD3D, CD3G and CD3E are transmembrane proteins with one extracellular immunoglobulin domain and one intracellular ITAM domain. The CD3 complex is a T-cell co-receptor that noncovalently associates with either the disulfide bound heterodimeric alpha/beta T-cell receptor (TCR) or gamma/delta TCR and two copies of the accessory protein, T-cell surface glycoprotein CD3 zeta chain (CD247), which is a transmembrane protein with three ITAM domains. The TCR moiety of the TCR-CD3 complex binds to MHC and processed antigens on antigen presenting cells, which triggers phosphorylation of and cellular propagation of the signal by CD247 and the CD3 complex.
Pruebas
The determination of cellular CD32b expression in a biological specimen.
For professionals
