Glossary Term
Major protein component of chromatin. Highly conserved basic proteins, originally classified into classes based on the relative amounts of arginine and lysine in each protein. The various classes are now termed H1, H2A, H2B, H3, and H4. In chromatin, they are found in an octamer, containing two each of H2A, H2B, H3, and H4, complexed with DNA in nucleosomes. The histones in the octamer complex are also known as the core histones. The H1 class of histones, termed the linker histones, is loosely associated with the nucleosome.
Pcr Terms
Pruebas
The determination of the amount of histone 2a antibody present in a sample.
For professionals
Indicadores
This gene is involved in histone modification.
Indicadores
This gene is involved in the modulation of histone methylation.
Indicadores
This gene is involved in epigenetic control of gene expression through histone methylation.
Indicadores
A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. (NCI04)
Indicadores
This gene is involved in epigenetic control of gene expression.
Indicadores
This gene is involved in chromatin structure.
Indicadores
This gene is involved in chromatin structure.
Pruebas
A determination of the amount of HDAC2 mRNA in a biological sample.
For professionals
