Technology
Loss of Heterozygosity Analysis
An analysis done to detect monoallelic loss of genes or DNA regions in a diploid cell.
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Technology
An analysis done to detect monoallelic loss of genes or DNA regions in a diploid cell.
Glossary Term
Having two different allelic forms of a gene, one inherited from each parent, on each of the two homologous chromosomes.
Glossary Term
A genetic variation where gain, loss, or exchange of DNA results in monoallelic loss of function mutations in a diploid cell. In the context of tumor suppressor genes, where a single copy is sufficient for functionality, loss of function for the second allele is associated with tumorigenesis.