Glossary Term
A 50-150bp DNA sequence that increases the rate of transcription of coding sequences. It may be located at various distances and in either orientation upstream from, downstream from or within a structural gene. When bound by a specific transcription factor it increases the levels of expression of the gene, but is not sufficient alone to cause expression. Distinguished from a promoter, that is alone sufficient to cause expression of the gene when bound.
Pcr Terms
Artículo
Research record from Mol Biol Rep, 2026-07-15. PMID 42455225.
Technology
An enhancement of immunoelectrophoresis in which a series of post-electrophoretic gel slabs are layered with cellulose-acetate gels saturated with specific antibodies. The resulting antigen-antibody complexes fixed on the second gel may then be stained, allowing sensitive and specific qualitative visual identification of paraproteins by electrophoretic position. It can be used to identify specific proteins in the blood or urine. It has greatest application in the identification and monitoring of monoclonal proteins that are produced in conditions like Waldenstom's macroglobulinaemia and multiple myeloma.
Diagnostic Methods
Artículo
Research record from Talanta, 2026-03-27. PMID 41905041.
Indicadores
The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body.
Artículo
Research record from J Vet Diagn Invest, 2026-06-01. PMID 42220103.
Indicadores
This gene plays a role in body weight homeostasis and cellular proliferation. Mutations in the gene are associated with acute myeloid leukemia.
Artículo
Research record from Biosens Bioelectron, 2026-03-03. PMID 41797024.
Pruebas
A complement blood test measures the levels and/or activity of a group of proteins that are part of the complement system. This system "complements" or enhances your body's defenses against infections and other diseases. Your immune system makes antibodies, which are proteins to fight disease-causing substances like viruses and bacteria. The proteins in the complement system will also help fight the infection or disease. These proteins work together in a sequence, with one protein activating the next.
For everyone & professionals
Artículo
Research record from Medicine (Baltimore), 2026-04-01. PMID 41961665.
Artículo
Research record from Interdiscip Perspect Infect Dis, 2026-04-20. PMID 42022756.
Artículo
Research record from J Neurol Sci, 2026-04-28. PMID 42049558.