Pruebas
CD3 Expressing Cell Count
The determination of the amount of the CD3 expressing cells in a sample.
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Pruebas
The determination of the amount of the CD3 expressing cells in a sample.
Pruebas
The measurement of the number T lymphocytes, which are leukocytes that express CD3, in a cubic millimeter of blood. It is calculated by multiplying 1000 by both the total leukocyte count and the percent of T cells in the differential leukocyte count.
Indicadores
A protein complex comprised of one T-cell surface glycoprotein CD3 delta chain (CD3D), one T-cell surface glycoprotein CD3 gamma chain (CD3G) and two T-cell surface glycoprotein CD3 epsilon chains (CD3E). CD3D, CD3G and CD3E are transmembrane proteins with one extracellular immunoglobulin domain and one intracellular ITAM domain. The CD3 complex is a T-cell co-receptor that noncovalently associates with either the disulfide bound heterodimeric alpha/beta T-cell receptor (TCR) or gamma/delta TCR and two copies of the accessory protein, T-cell surface glycoprotein CD3 zeta chain (CD247), which is a transmembrane protein with three ITAM domains. The TCR moiety of the TCR-CD3 complex binds to MHC and processed antigens on antigen presenting cells, which triggers phosphorylation of and cellular propagation of the signal by CD247 and the CD3 complex.
Artículo
Research record from EBioMedicine, 2026-08-12. PMID 42585989.