Technology
A procedure used to demonstrate nucleotide sequence variations that occur in the same region of DNA between individuals within a species, or between alleles in an individual to detect mutations in various genes, such as oncogenes, tumor suppressor genes, or genes responsible for genetic diseases. The method detects different conformations adopted by partially denatured DNA fragments resulting from their specific nucleotide sequences under denaturing conditions. Denatured single-stranded DNA fragments are allowed to partially renature without formation of double-stranded DNA. The particular conformations adopted by each of the renatured fragments depend on each of their specific nucleotide sequences. The fragments are run on polyacrylamide gels to detect subtle changes in migration due to their particular secondary structures. Resulting fragment band in the gel will misalign if any point mutations are present to alter the conformation.
Diagnostic Methods
Company
Standard BioTools Inc. is an IVD supplier based in United States, with a source-linked product portfolio. Molecular Assays. Coverage spans Molecular Assays | qPCR.
Manufacturer
Technology
An isothermal, in vitro nucleic acid amplification method that allows primer-directed amplification of a target sequence. It utilizes a primer that can be nicked to create a polymerase start site and a DNA polymerase that will displace a downstream strand as it tracks along the template.
Diagnostic Methods
Technology
A quantum optical-electrical phenomena consisting of an alteration in light reflectance as a result of binding of molecules to a surface from which total internal reflection is occurring. Used to detect macromolecular interactions, SPR can be used as the basis for a sensor which is capable of sensitive and quantitative measurement of a broad spectrum of chemical and biological entities.
Diagnostic Methods
Company
Sysmex is an IVD supplier based in Japan, with a source-linked product portfolio. Hematology. Coverage spans Instruments, Sample Preparation.
Manufacturer
Technology
Mass spectrometers coupled in series. The targeted compound is selectively ionized, and its characteristic ions are separated from others in the mixture in the first mass spectrometer. The selected primary ions are then decomposed by collision, and from the resulting products the final mass analyzer selects secondary ions characteristic of the targeted compound. Tandem mass spectrometry can achieve specificities and sensitivities equivalent of those of methods such as radioimmunoassay and gas chromatography/mass spectrometry, while performing analyses in much shorter times.
Diagnostic Methods
Company
Tecan Group AG is an IVD supplier based in Switzerland, with a source-linked product portfolio. Liquid handling automation, Microplate readers, NGS solutions, OEM components. Coverage spans Automation | Workflow Automation.
Manufacturer
Company
of a 40,000 square foot manufacturing plant in Anaheim, California. We ship to over 100 countries worldwide, ranging from everyday consumers to hospitals and governmental
Manufacturer
Company
Czech company engaged in development, manufacturing and distribution of both human and veterinary diagnostics. Our broad spectrum of in vitro diagnostics and knowledge in the
Manufacturer
Company
Thermo Fisher Scientific Inc. is an IVD supplier based in United States, with a source-linked product portfolio. Molecular Diagnostics. Coverage spans Molecular Assays, Instruments, Sample Preparation | RT-PCR | STI.
Manufacturer
Company
Tianlong (天隆科技) is an IVD supplier based in China, with a source-linked product portfolio. PCR Systems. Coverage spans Instruments, Sample Preparation, Molecular Assays | RT-PCR, Nucleic Acid Extraction, qPCR | Bloodborne, Respiratory, Gastrointestinal.
Manufacturer
Company
over 35 years. We develop, manufacture, and supply Real-Time PCR kits, primer/probe sets, and key components used in medical diagnostics, research, and industrial manufacturing worldwide.
Manufacturer
