National Cancer Institute (source definition)
Liquid Chromatography/Tandem Mass Spectrometry
An analytical technique wherein liquid chromatography is coupled to tandem mass spectrometry in order to separate, identify, and quantify substances in a sample.
Review and references
Automated source check (NCI definition)
2026-10-20
2026-10-30
professional use
References
- NCI Thesaurus 26.09d — Liquid Chromatography/Tandem Mass Spectrometry (C122168)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C122168. NCI definition, reproduced without modification under CC BY 4.0.
- Analytical Strategies for the Identification and Differentiation of Positional Isomers of N-(2-Methoxybenzyl)-2-(trimethoxyphenyl)ethanamines by Chromatography and Mass Spectrometry. — Drug Test Anal, 2026-10-20 (PMID 42899788; literature)
- New test method for determination of extractable per- and polyfluoroalkyl substances (PFAS) in consumer products by solvent extraction followed by liquid chromatography tandem mass spectrometry (LC-MS/MS). — Environ Monit Assess, 2026-10-16 (PMID 42888347; literature)
- Re-Evaluation of the Diagnostic Cut-Off for the Overnight Metyrapone Test Using Liquid Chromatography-Tandem Mass Spectrometry Measurement of 11-Deoxycortisol. — Horm Metab Res, 2026-10-23 (PMID 42915320; literature)
- Method optimization and verification of homovanillic acid (HVA), vanillylmandelic acid (VMA) and 5-hydroxyindoleacetic acid (5-HIAA) on liquid chromatography tandem mass spectrometry (LC-MS/MS). — Clin Biochem, 2026-10-22 (PMID 42913769; literature)
- Quantification of Upadacitinib, Dasatinib, Ruxolitinib, Imatinib, and Cabozantinib in Plasma With Liquid Chromatography-Tandem Mass Spectrometry. — Ther Drug Monit, 2026-10-28 (PMID 42949034; literature)
What it is
An analytical technique wherein liquid chromatography is coupled to tandem mass spectrometry in order to separate, identify, and quantify substances in a sample.
Source: National Cancer Institute, NCI Thesaurus 26.09d, C122168. NCI definition, reproduced without modification under CC BY 4.0.
Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Compliance note
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Explore more
Same category
Tissue Culture Infectious Dose 50%
A potency unit defined as a minimal dose of infectious material at which preparation causes cytopathic effects (changes in the morphology and metabolism of tissue culture cells, indicatin…
Same categoryEpsilometry
A method to determine microbial susceptibility to antibiotics in which a plastic strip impregnated with the antibiotic of interest is placed on an agar plate that has been inoculated with…
Same categoryViral Identification
A diagnostic procedure to identify and characterize a viral organism.