National Cancer Institute (source definition)
Liquid Chromatography Mass Spectrometry
LC/MS is a hyphenated technique, combining the separation power of liquid chromatography (LC), an analytical chromatographic technique for separating ions or molecules dissolved in a solvent, with the detection power of mass spectrometry(MS), a technique to separate gas phase ions according their m/z (mass to charge ratio) value. Used for drug screening, pharmacology studies, environmental analyses and forensics.
Review and references
Automated source check (NCI definition)
2026-10-18
2026-10-29
professional use
References
- NCI Thesaurus 26.09d — Liquid Chromatography Mass Spectrometry (C18475)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C18475. NCI definition, reproduced without modification under CC BY 4.0.
- Orthogonality-driven offline two-dimensional liquid chromatography coupled with high-resolution mass spectrometry for comprehensive chemical profiling and quality marker screening of Renshen Guben oral liquid. — Anal Bioanal Chem, 2026-10-08 (PMID 42848077; literature)
- Characterization of functional yogurt enriched with liquid sugarcane molasses: physicochemical, sugar profile, color properties, and liquid chromatography-mass spectrometry profiling of molasses phenolic acids. — Ital J Food Saf, 2026-10-12 (PMID 42867286; literature)
- Extending the separation space in online comprehensive two-dimensional liquid chromatography-mass spectrometry through second-dimension column switching: Application to Tamarindus indica L. — J Chromatogr A, 2026-10-09 (PMID 42874453; literature)
- Spatial modulation enhances the effects of radiation on prostate cancer cells: a targeted mass spectrometry metabolomics study. — Int J Radiat Biol, 2026-10-20 (PMID 42900628; literature)
- Liquid chromatography-mass spectrometry approaches for analysis of polychlorinated alkanes: a review. — Environ Sci Pollut Res Int, 2026-10-24 (PMID 42925464; literature)
- Highly sensitive determination of polyunsaturated fatty acids by permanently charged derivatization-liquid chromatography-electrospray ionization tandem mass spectrometry. — Anal Sci, 2026-10-27 (PMID 42934419; literature)
What it is
LC/MS is a hyphenated technique, combining the separation power of liquid chromatography (LC), an analytical chromatographic technique for separating ions or molecules dissolved in a solvent, with the detection power of mass spectrometry(MS), a technique to separate gas phase ions according their m/z (mass to charge ratio) value. Used for drug screening, pharmacology studies, environmental analyses and forensics.
Source: National Cancer Institute, NCI Thesaurus 26.09d, C18475. NCI definition, reproduced without modification under CC BY 4.0.
Source identity and definition checked automatically on 2026-10-18. No individual clinical interpretation or human reviewer is asserted.
Compliance note
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
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