Indicators
ABL1 Gene
This gene is involved in cell adhesion, differentiation, division and stress response.
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Indicators
This gene is involved in cell adhesion, differentiation, division and stress response.
Indicators
A fusion gene that results from a translocation t(9;22)(q34;q11) that fuses the 5' part of the BCR gene to the 5' side of exon 2 of the ABL1 gene. There are 3 potential products that are formed depending on which BCR exon has the breakpoint. All of the protein products have constitutively active tyrosine kinase activity. This fusion is associated with both chronic myeloid leukemia and acute lymphoblastic leukemia.
Indicators
This gene plays a role in body weight homeostasis and cellular proliferation. Mutations in the gene are associated with acute myeloid leukemia.
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This gene plays a role in cellular hematopoiesis and differentiations. Mutations in the gene are associated with several diseases, including acute myelogenous leukemia, gastrointestinal tumors, and mast cell disease.
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This gene is involved in transcriptional regulation and alterations in the gene are associated with acute lymphoblastic leukemia.
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This gene plays a role in cell cycle progression and apoptosis. Cytogenetic aberrations in the gene are involved in cellular transformation and are associated with a variety of hematopoietic tumors, leukemias and lymphomas.
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This gene plays a role in mitogenic activities affecting mesenchymal cells and a translocation in the gene results in chronic myelomonocytic leukemia.
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This gene is involved in cell growth, proliferation, differentiation and migration. It also plays a role in apoptosis.
Indicators
This gene plays a role in transcriptional regulation and cytogenetic aberrations are associated with several leukemias.
Indicators
Tumor-associated oncofetal glycoprotein 72 (TAG-72) is a high molecular weight (220-400 kD) complex expressed by a wide variety of human adenocarcinomas. This antigen is expressed by a majority of invasive ductal breast carcinomas, and most colon, pancreatic, gastric, esophageal, lung (non-small cell), ovarian and endometrial adenocarcinomas, and on normal secretory endometrium, but not on other normal tissues. It is not expressed by leukemias, lymphomas, sarcomas, mesotheliomas, melanomas or benign tumors. The monoclonal antibodies against TAG-72 have been widely employed for the immunohistochemical analysis of adenocarcinomas as well as for radioimmunoscintigraphy and radioimmunoguided surgery.