Article
Significance of next-generation sequencing in the era of targeted therapy for biliary tract cancer: an analysis at a single institution.
Research record from Explor Target Antitumor Ther, 2026-09-18. PMID 42761668.
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Article
Research record from Explor Target Antitumor Ther, 2026-09-18. PMID 42761668.
Glossary Term
A point mutation occurring within the protein-coding region of a gene, and which codes for the same amino acid as expected.
Glossary Term
A natural compound of silicon and oxygen found mostly in sand, Silica has three main crystalline varieties: quartz, tridymite, and cristobalite. Fine particulate silica dust from quartz rock causes over a long-term progressive lung injury, silicosis. (NCI04)
Glossary Term
A variation of a single nucleotide at a specific location of the genome due to base substitution, present at an appreciable frequency between individuals of a single interbreeding population.
Glossary Term
A variation of a single nucleotide at a specific location of the genome due to base substitution, which is found at any frequency in the population.
Glossary Term
A long linear single-stranded polymer formed from nucleotides attached to a deoxyribose backbone.
Indicators
A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04)
Tests
The determination of the ratio of the skin-homing cytotoxic central memory T-lymphocytes to total cytotoxic central memory T-lymphocytes present in a sample. The measurement may be expressed as a ratio or percentage.
Tests
The determination of the ratio of a sub-population of skin-homing cytotoxic memory T-lymphocytes to total cytotoxic T-lymphocytes present in a sample. The measurement may be expressed as a ratio or percentage.
Tests
The determination of the gut-homing helper memory T-lymphocytes present in a sample.
Tests
The determination of the skin-homing helper terminal memory T-lymphocytes present in a sample.
Glossary Term
A 20 to 25-nucleotide double-stranded RNA which is involved in a sequence-specific messenger RNA degradation process known as RNA interference.