Glossary Term
Single Nucleotide Polymorphism
PCR TermsEN
Definition
A variation of a single nucleotide at a specific location of the genome due to base substitution, present at an appreciable frequency between individuals of a single interbreeding population.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C18279. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-18. No individual clinical interpretation or human reviewer is asserted.
Also Known As
Polymorphism, Single BasePolymorphism, Single NucleotideSingle Nucleotide PolymorphismSNP
References
- NCI Thesaurus 26.09d — Single Nucleotide Polymorphism (C18279)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C18279. NCI definition, reproduced without modification under CC BY 4.0.
- Sex-Specific Effects of the rs9896243 Single Nucleotide Polymorphism on Verbal Memory in First Episode Psychosis: A Family-Based Approach. — Span J Psychiatry Ment Health, 2026-10-07 (PMID 42843653; literature)
- Uracil-DNA glycosylase-engineered recombinase polymerase amplification for single-nucleotide polymorphism discrimination and genotyping. — Anal Methods, 2026-10-02 (PMID 42825452; literature)
- Clinical Implications of the Novel Genetic Polymorphism Associated With Retinal Vein Occlusion: The East Asian GWAS Survey in a Single-Center Taiwanese Cohort. — Transl Vis Sci Technol, 2026-10-01 (PMID 42852991; literature)
- In silico prediction and functional analysis of non-synonymous single-nucleotide polymorphisms (nsSNPs) in human ACTL7A gene associated with spermatogenesis. — Asian J Androl, 2026-10-13 (PMID 42868063; literature)
- Results from the VANISH study: A prospective multicenter study validating a single-nucleotide polymorphism-based noninvasive prenatal test to assess aneuploidy risk in surviving twins of vanishing twin pregnancies. — Pregnancy (Hoboken), 2026-10-21 (PMID 42909945; literature)
- Single-nucleotide polymorphism-directed design of allele-specific antisense oligonucleotides for spinocerebellar ataxia type 3. — Sci Transl Med, 2026-10-21 (PMID 42905853; literature)