Indicators
MYCL Gene
This gene is involved in transcriptional regulation and is frequently amplified in small-cell lung cancer.
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Indicators
This gene is involved in transcriptional regulation and is frequently amplified in small-cell lung cancer.
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This gene plays a role in DNA repair and cell cycle checkpoints.
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This gene plays a role in cell adhesion and cytoskeletal remodeling. It is also involved in suppression of cell growth.
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This gene plays a role in cell-cell signaling.
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This gene plays a role in both intercellular signaling and cell fate determination.
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This gene plays a role in signal transduction and cell cycle regulation.
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Osteopontin (314 aa, ~35 kDa) is encoded by the human SPP1 gene. This protein is involved in the regulation of both tissue mineralization and cell-cell signaling.
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This gene is involved in the transcriptional regulation of target genes. It plays a role in B-cell differentiation, neural development and spermatogenesis.
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This gene is involved in second messenger signaling, apoptosis, cell growth and angiogenesis.
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Plasminogen activator inhibitor 1 (402 aa, ~45 kDa) is encoded by the human SERPINE1 gene. This protein plays a role in both cell adhesion and the modulation of plasmin activity.
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A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. (NCI04)
Indicators
This gene plays a role in signal transduction and apoptosis. It is also involved in the regulation of cell cycle progression.