Indicator Explainer
Osteopontin
Osteopontin (314 aa, ~35 kDa) is encoded by the human SPP1 gene. This protein is involved in the regulation of both tissue mineralization and cell-cell signaling.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C46082. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
Related Tests
Tests that measure or involve this indicator.
References
- NCI Thesaurus 26.09d — Osteopontin (C46082)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C46082. NCI definition, reproduced without modification under CC BY 4.0.
- Osteopontin induces cyclo-oxygenase-2 expression in osteoclasts. — Cell Signal, 2026-10-20 (PMID 42901287; literature)
- Effects of intravaginal infusion of the osteopontin peptide possessing integrin-binding motifs on an inflammation-like response in the endometrium of dairy cows. — J Reprod Dev, 2026-10-16 (PMID 42893853; literature)
- Osteopontin primary transcript generates exonic circRNA molecules by back splicing in tumor cell lines. — Gene, 2026-10-23 (PMID 42918430; literature)
- [A prospective birth cohort study on the association between human milk osteopontin and infant physical growth]. — Zhonghua Er Ke Za Zhi, 2026-10-15 (PMID 42876099; literature)
- Unipoint-anchored cascade amplification strategy integrating FUSE probe-activated CRISPR-Cas12a for dual mode osteopontin detection toward osteosarcoma assessment and therapeutic response evaluation. — Biosens Bioelectron, 2026-10-13 (PMID 42892233; literature)
- A Pyrrole-Imidazole Polyamide Targeting Human USF1 Binding Suppresses High Glucose-Induced TGF-β1 and Osteopontin Expression in Human Renal Mesangial Cells. — Cells, 2026-10-06 (PMID 42882515; literature)