Loading
Search products, companies, tests, and guides — go from query to quote request in one place.
Indicators
A physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression.
Indicators
Gonadal glycoprotein hormone, Inhibin A, consists of an alpha subunit covalently linked to a beta-A subunit and strongly inhibits pituitary FSH secretion. Serum concentrations transit during the menstrual cycle. Dimers of the beta subunit (a TGF-beta superfamily member), termed activin, are potent stimulators of FSH secretion. (from OMIM 147380 and NCI)
Indicators
Inhibin B, consisting of an alpha subunit and a beta B subunit linked by disulphide bonds, is a heterodimer hormone produced by the follicle cells of the ovary and by the Sertoli and Ledig cells of testis. Although other forms of inhibin also exist in men, inhibin B is the predominant form in the circulation in men.
Indicators
A class of interferon (leukocyte interferon) produced predominantly by B lymphocytes. Located in a cluster on 9p22 there are at least 13 functional genes and 1 pseudogene.
Indicators
A heterodimeric cytokine composed of interleukin-12 subunit beta and interleukin-23 subunit alpha. This complex binds to the interleukin-23 receptor complex, which activates the JAK-STAT signaling pathway and modulates the proliferation, differentiation and effector functions of T-lymphocytes, natural killer cells and some myeloid lineage cells.
Indicators
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.
Indicators
Neutrophil gelatinase-associated lipocalin (198 aa, ~23 kDa) is encoded by the human LCN2 gene. This protein may play a role in iron transport, apoptosis, and innate immunity.
Indicators
This gene plays a role in mitogenic activities affecting mesenchymal cells and is involved in receptor tyrosine kinase signal transduction.
Indicators
This gene is involved in second messenger signaling, apoptosis, cell growth and angiogenesis.
Indicators
This gene plays a role in the regulation of protein kinase A.
Indicators
This gene plays a role in transcription and retinoic acid receptor signal transduction.
Indicators
A heat-labile and water-soluble essential vitamin, belonging to the vitamin B family, with antioxidant, erythropoietic, mood modulating, and glucose-regulating activities. Thiamine reacts with adenosine triphosphate (ATP) to form an active coenzyme, thiamine pyrophosphate. Thiamine pyrophosphate is necessary for the actions of pyruvate dehydrogenase and alpha-ketoglutarate in carbohydrate metabolism and for the actions of transketolase, an enzyme that plays an important role in the pentose phosphate pathway. Thiamine plays a key role in intracellular glucose metabolism and may inhibit the action of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine may also protect against lead toxicity by inhibiting lead-induced lipid peroxidation.
