Indicators
SPOP Gene
This gene is involved in protein ubiquitination, which often leads to proteasomal degradation.
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Indicators
This gene is involved in protein ubiquitination, which often leads to proteasomal degradation.
Indicators
This gene is involved in apoptosis, hormonogenesis, focal adhesion and the formation of intercellular junctions.
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This gene plays a role in signal transduction and activation of transcription. It is involved in regulation of both apoptosis and cell growth.
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This gene is involved in signal transduction and activation of transcription. It plays a role in the immune response via stimulation of T-cell proliferation.
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This gene plays a role in the regulation of both transcription and signaling.
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A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.
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This gene is involved in cell cycle regulation and telomere maintenance.
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This gene is involved in transcriptional regulation and cell cycle progression regulation.
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This gene plays a role in cellular proliferation and mitogenic responses.
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A natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Physiologically, this agent relaxes bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm. (NCI04)
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An essential amino acid in humans (provided by food), Threonine is an important residue of many proteins, such as tooth enamel, collagen, and elastin. An important amino acid for the nervous system, threonine also plays an important role in porphyrin and fat metabolism and prevents fat buildup in the liver. Useful with intestinal disorders and indigestion, threonine has also been used to alleviate anxiety and mild depression. (NCI04)
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Tissue-type plasminogen activator (562 aa, ~63 kDa) is encoded by the human PLAT gene. This protein plays a role in the cleavage of plasminogen between Arg-580 and Val-581 to form the fibrinolytic enzyme plasmin.