Indicator Explainer
Tissue-Type Plasminogen Activator
Tissue-type plasminogen activator (562 aa, ~63 kDa) is encoded by the human PLAT gene. This protein plays a role in the cleavage of plasminogen between Arg-580 and Val-581 to form the fibrinolytic enzyme plasmin.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C16995. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — Tissue-Type Plasminogen Activator (C16995)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C16995. NCI definition, reproduced without modification under CC BY 4.0.
- Novel Roles of Urokinase- and Tissue-Type Plasminogen Activators in Substance Use Disorders: A Narrative Review of Molecular Mechanisms and Translational Perspectives. — Int J Mol Sci, 2026-08-19 (PMID 42653404; literature)
- Ultrasound-Assisted Catheter-Directed Thrombolysis vs. Low-Dose Intravenous Tissue-Type Plasminogen Activator Treatments in Acute Intermediate-High Risk Pulmonary Embolism: Insights from a Retrospective Study. — Anatol J Cardiol, 2026-08-04 (PMID 42552776; literature)
- Tissue-type plasminogen activator protects against kidney damage in invasive fungal infection. — J Exp Med, 2026-07-21 (PMID 42479027; literature)