Indicators
RNF43 Gene
This gene is involved in both protein ubiquitination and the Wnt signaling pathway.
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Indicators
This gene is involved in both protein ubiquitination and the Wnt signaling pathway.
Indicators
Sclerostin (213 aa, ~24 kDa) is encoded by the human SOST gene. This protein plays a role in the regulation of bone growth and Wnt signaling pathways.
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Secretogranin-1 (677 aa, ~78 kDa) is encoded by the human CHGB gene. This protein may play a role in the synthesis of biologically active peptides.
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A nonmetallic chemical element found in trace amounts in human body. Selenium primarily occurs in vivo as selenocompounds, mostly selenoproteins such as glutathione peroxidase and thioredoxin reductase (enzymes responsible for detoxification). Alone or in combination with Vitamin E, selenocompounds act as antioxidants. These agents scavenge free radicals; prevent blood clots by inhibiting platelet aggregation; strengthen the immune system; and have been shown, in some instances, to inhibit chromosomal damage and mutations. Exhibiting chemopreventive activity, selenocompounds also inhibit the induction of protein kinase C.
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A non-essential amino acid in humans (synthesized by the body), Serine is present and functionally important in many proteins. With an alcohol group, serine is needed for the metabolism of fats, fatty acids, and cell membranes; muscle growth; and a healthy immune system. It also plays a major role in pyrimidine, purine, creatine, and porphyrin biosynthetic pathways. Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin. (NCI04)
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Serotransferrin (698 aa, ~77 kDa) is encoded by the human TF gene. This protein is involved in iron sequestration and transport.
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A family of apolipoproteins that are associated with high-density lipoprotein particles in the serum. These proteins may play a role in both the acute-phase of inflammation and in cholesterol transport.
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This gene may be involved in the modulation of protein SET activity.
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Sex hormone-binding globulin (402 aa, ~44 kDa) is encoded by the human SHBG gene. This protein is involved in steroid transport.
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A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04)
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This gene plays a role in G protein-coupled receptor signal transduction and sonic hedgehog pathway activation.
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Soluble monocyte differentiation antigen CD14 is encoded by the human CD14 gene. This soluble protein may be used as a marker of monocyte activation and is derived either through cleavage that removes the glycophosphoinositol (GPI)-anchor from the membrane bound form of CD14 or as non-cleaved form secreted from the non-GPI-modified intracellular pool of CD14.