Indicator Explainer
Sclerostin
Sclerostin (213 aa, ~24 kDa) is encoded by the human SOST gene. This protein plays a role in the regulation of bone growth and Wnt signaling pathways.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C105078. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — Sclerostin (C105078)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C105078. NCI definition, reproduced without modification under CC BY 4.0.
- Micro-CT-derived nonlinear micro-finite element estimation of compressive fracture load in murine vertebrae: a pilot feasibility study in sclerostin antibody-treated and control mice. — Med Eng Phys, 2026-10-09 (PMID 42854711; literature)
- Sclerostin regulates bone morphogenetic protein (BMP) bioavailability through interactions with BMP complexes and fibrillin microfibrils. — FEBS J, 2026-09-29 (PMID 42808166; literature)
- Osteoporosis and Alzheimer's Disease: The Role of Sclerostin. — Curr Osteoporos Rep, 2026-10-21 (PMID 42905237; literature)
- Safety, pharmacokinetics, pharmacodynamics and target-mediated drug disposition modeling of TST002, a sclerostin antibody, in men and postmenopausal women with low bone mineral density. — Expert Opin Investig Drugs, 2026-09-22 (PMID 42747328; literature)
- The role of sclerostin in spinal cord injury: A scoping review. — J Spinal Cord Med, 2026-09-17 (PMID 42752329; literature)
- Self-Assembled Aptamer-Derived PROTAC Enables Efficient Cellular Internalization for Intracellular Sclerostin Degradation and Triple-Negative Breast Cancer Therapy. — Adv Healthc Mater, 2026-09-13 (PMID 42733185; literature)